Objective: Intrinsic atopic dermatitis (AD) is a chronic inflammatory skin disease with pruritus and eczematous lesions of skin. A long-lasting cycle of itch-scratch roots results in substantial morbidities and discomfort. Treatment of patients with moderate to severe dermatitis is a challenge. To evaluate the efficacy of a treatment based on mineral salts and natural antioxidants agents in patients with AD.

Patients and Methods: In this prospective study, 34 patients with AD were treated for 14 days. Patients were evaluated before and after treatment. The effects were studied by the following clinical measurements: Eczema Area and Severity Index (EASI), Scoring Atopic Dermatitis (SCORAD), Body Surface Area (BSA), and Validated Investigator Global Assessment for Atopic Dermatitis (vIGA-AD). Patient-reported measurements were also assessed: Patient-Oriented Eczema Measure (POEM), Dermatology Life Quality Index (DLQI), and the pruritus Numeric Rating Scale (NRS). Biopsies were performed in 10 patients and immunohistochemistry tests in 7 patients.

Results: All clinical and patient-reported measurements showed a strong difference before and after treatment. The epidermis thickness was significantly reduced, as well as the lymphocyte infiltration and the reduction of CD3, CD4, CD8, CD20 and CD117 cells. No adverse events were observed.

Conclusion: This study shows that the severity of intrinsic dermatitis was drastically reduced with the treatment of mineral salts and natural antioxidants agents. This topic treatment was very well tolerated without adverse events.

Ignacio Umbert, MD, PhD, is a third-generation dermatologist from Barcelona, Spain, and the Director and Founder of the Ignacio Umbert Institute of Dermatology. He has specialized in clinical dermatology, dermatopathology, dermatoimmunology, inflammatory skin diseases, and personalized dermatological treatment.

He obtained his degree in Medicine and Surgery from the University of Barcelona in 1980 and subsequently trained at internationally recognized institutions, including the Mayo Clinic and Mayo Medical School, New York University, and the University of Edinburgh. His advanced training included fellowships in dermatopathology and dermatoimmunology. He received his Doctorate in Medicine (Cum Laude) from the University of Barcelona in 1990 and ranked first in Spain's examination for the specialist title in Medical-Surgical Dermatology and Venereology in 1988.