Introduction: Acne is a common disorder of the pilosebaceous unit, resulting from increased sebum secretion and the colonization of Propionibacterium. Scarring is the most common consequence of acne and can significantly affect patients' quality of life.

Methods: Patients with moderate to severe facial acne scars who were referred to the dermatology clinic in 2023 were enrolled. All patients underwent endo-radiofrequency subcision (Endo-RF subcision) on both sides of the face, with platelet-rich plasma (PRP) administered on one side only. Scarring was assessed using quantitative and qualitative measures based on the Goodman and Baron's global scarring grading system.

Results: Ten patients (eight females and two males) completed the study. Although qualitative scores improved in both groups, no statistically significant difference was observed. There was no significant correlation in the percentage of recovery between the two study groups (Endo-RF and PRP + Endo-RF) before and after treatment. Evaluations of the quantitative scores for both groups showed considerable improvements in the number of acne scars. A strongly significant correlation was observed in both groups compared to baseline. Although the combination therapy group showed greater improvement in quantitative scar scores from baseline, the difference was not statistically significant.

Conclusion: Both Endo-RF subcision and PRP combined with Endo-RF subcision are safe and effective modalities for treating post-acne scars. Although each method can improve acne scars, the combination therapy of Endo-RF with PRP may yield more desirable results.

Fatemeh Rastaghi is a dermatologist and clinical researcher affiliated with the Department of Dermatology, Afzalipour Hospital, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran. She is currently a dermatology resident and has served as Chief Resident at Kerman University of Medical Sciences. Her research focuses on clinical and cosmetic dermatology, with particular interests in alopecia, pigmentary disorders, acne scar management, psoriasis, autoimmune skin diseases, and aesthetic dermatology. She has contributed to several peer-reviewed publications, including studies on alopecia areata, periorbital hyperpigmentation, psoriasis epidemiology, and cosmetic treatment modalities. In addition to her clinical practice, Dr. Rastaghi has experience in molecular and translational dermatology research, including PCR, RNA sequencing, bioinformatics, and evidence-based clinical investigations, supporting advancements in both medical and aesthetic dermatology.